I think South of Broad by Pat Conroy has been showing up in a lot of mailboxes. The blurb on the back cover says:
"Against the sumptuous backdrop of Charleston, South Carolina, South of Broad gathers a unique cast of sinners and saints. Leopold Bloom King, our narrator, is the son of an amiable, loving father who teaches science at the local high school. His mother, an ex-nun, is the high school principal and a respected Joyce scholar. After Leo's older brother commits suicide at the age of ten, the family struggles with the shattering effects of his death, and Leo, lonely and isolated, searches for something to sustain him. Eventually, he finds his answer when he becomes part of a tightly knit group of high school seniors that includes friends Sheba and Trevor Poe, glamorous twins with an alcoholic mother and a prison-escapee father; hardscrabble mountain runaways Niles and Starla Whitehead; socialite Molly Huger and her boyfriend, Chadworth Rutledge X-and an ever-widening circle whose liaisons will ripple across two decades, from 1960s counterculture through the dawn of the AIDS crisis in the 1980s."
The ARC has 512 pages and the tentative on-sale date is September 15, 2009. It looks really good!